Animal study: L-citrulline supplementation accelerates healing of broken bones


12 shares

Animal study: L-citrulline supplementation accelerates healing of broken bones

Animal study: L-citrulline supplementation accelerates healing of broken bones


People who have broken a bone may promote their healing process by supplementing with the amino acid L-citrulline. This is suggested by an animal study that Dutch researchers at Maastricht University Medical Center published in European Cells and Materials.

Study
The researchers experimented with old female mice, surgically sawing the bone in their hind legs into two pieces, and then re-joining them with screws. In doing so, however, the researchers left a little space between the two parts of the bone, so the bone had to form new bone tissue.

The researchers gave the test animals 4.6-5 grams of arginine or citrulline per kilogram of body weight daily. These were the experimental groups.

If the mice had been human adults, they would have received about 30 grams of citrulline daily. That’s a lot – and maybe too much. In most human studies, subjects are given only 2-8 grams of citrulline per day.

Mice in a control group received no additional amino acids.

Results
The researchers scanned the bones 14 days after the procedure. The scans showed that supplementation with the amino acids – especially supplementation with citrulline – accelerated the healing of bone tissue.

Animal study: L-citrulline supplementation accelerates healing of broken bones

Animal study: L-citrulline supplementation accelerates healing of broken bones

Animal study: L-citrulline supplementation accelerates healing of broken bones

The mice also lost less weight after surgery due to amino acid supplementation. This may implicate that citrulline, and to a lesser extent arginine, enhanced the animals’ entire health during the healing process.

400-mg capsule of L-ornithine improves sleep

Mechanism
The researchers believe that citrulline, and to a lesser extent arginine, accelerates bone fracture healing by converting citrulline into building blocks of collagen in bone tissue.

In addition, citrulline may also stimulate the construction of new blood vessels, so that new bone tissues can be supplied with more oxygen and nutrients.

Source:
Eur Cell Mater. 2020 Mar 20;39:183-92.

More:
MSM, growth hormone and IGF-1 | Stronger bones, stronger muscles? 11.06.2020
Gelatine-based Fortibone makes bones stronger 12.05.2018
Gelatin makes intensive exercise even more effective against bone loss 18.12.2017

Archives:
Building Strong Bones
Amino Acids
L-Citrulline


What's Your Reaction?

confused confused
0
confused
cute cute
0
cute
fail fail
0
fail
hate hate
0
hate
lol lol
0
lol
love love
0
love
omg omg
0
omg
vomit vomit
0
vomit
win win
0
win
Choose A Format
Personality quiz
Series of questions that intends to reveal something about the personality
Trivia quiz
Series of questions with right and wrong answers that intends to check knowledge
Poll
Voting to make decisions or determine opinions
Story
Formatted Text with Embeds and Visuals
List
The Classic Internet Listicles
Countdown
The Classic Internet Countdowns
Open List
Submit your own item and vote up for the best submission
Ranked List
Upvote or downvote to decide the best list item
Meme
Upload your own images to make custom memes
Video
Youtube, Vimeo or Vine Embeds
Audio
Soundcloud or Mixcloud Embeds
Image
Photo or GIF
Gif
GIF format