Black pepper extract PipeNig-FL stimulates muscle growth while inhibiting body fat growth
Black pepper extract PipeNig-FL promotes muscle growth while inhibiting body fat growth
A brand-new extract of black pepper– Piper nigrum in Latin– might help athletes to construct more muscle mass and at the same time obstruct the development of their fat mass. According to an in vitro research study that Italian biologists from the University of Turin released in Nutrients, the active compounds in the extract are active in a concentration of 1 nanomol.
PipeNig-FL is an extract of black pepper and an item of the Italian component producer Biosfered. [biosfered.com] Biosfered paid part of the expenses of the research study that this posting is about. Additionally, among the co-authors of the publication was a Biosfered worker.
When sports supplement users come across black pepper extracts, they typically consist of bioperine. Because bioperine in the small intestine removes some enzymes, the uptake of a large range of bioactive compounds increases. Nevertheless, PipeNig-FL is a completely different type of extract. It generally includes trans-beta-caryophyllene [structural formula at the top of the page]
Listed below you can see the structure of PipeNig-FL.
Biosfered has had human research carried out into the analgesic impact of PipeNig-NL, but thinks that the brand-new extract has much more interesting biological impacts. For this reason the in vitro research by the University of Turin.
When the scientists exposed muscle cells in test tubes to a labeled type of glucose and PipeNig-FL, they saw that the extract increased glucose uptake by muscle cells. In muscle cells trans-beta-caryophyllene activated the glucose transporter GLUT4 [bottom right] That happened in a concentration of 1 nanomol [bottom left]– which is remarkably low.
In fat cells, trans-beta-caryophyllene obstructed the increase in the amount of stored fat [top right] Fat cells biosynthesize that fat primarily by transforming glucose. Obviously, trans-beta-caryophyllene inhibits the uptake of glucose from fat cells. Nevertheless, the active substance in PipeNig-FL was not hazardous to the fat cells.
“GLUT4 levels are significantly reduced in the skeletal muscle or type 2 diabetic patients and in insulin resistant patients”, the researchers write. “The development of therapeutic compounds able to induce GLUT4 expression/translocation can thus improve insulin sensitivity and reduce insulin resistance.”
“Several plant-derived bioactive molecules have been listed as stimulators of GLUT4 translocation and/or expression, among these resveratrol, chlorogenic acid, daidzein, curcumin and astaxanthin. As a major component of PipeNig-FL, trans-beta-caryophyllene, could now be included in this list.”